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Lose his soul - a Christian perspective
It does no good for somebody to amass immense wealth but die without knowing Christ. We ought to work at getting our hearts right, and not be distracted by the temptation to seek after earthly wealth.

http://biblegateway.com/passage/?search=Matthew%2016:26&version=NIV

Gain the world - a Christian perspective
In Matthew, Jesus asks what if it's worth losing your soul to gain the world. He then asks what a man's soul is worth, what should he gain for it's trade?

http://biblegateway.com/passage/?search=Matthew%2016:26&version=KJV